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sodium fluoride pot nitrate Dent
This medication is used to prevent cavities and to reduce pain from sensitive teeth (dentinal hypersensitivity). Sodium fluoride works by making the teeth stronger and more resistant to decay caused by acid and bacteria. Potassium nitrate works by calming the nerves in the teeth.
Do not use this medication in children younger than 12 years old unless directed to do so by your doctor/dentist.
How to use sodium fluoride-pot nitrate DentUse this medication usually twice daily (in the morning and evening) or as directed by your doctor/dentist.
Use this medication in place of your regular toothpaste unless otherwise directed by your doctor/dentist. Apply at least a 1 inch (2.5 centimeters) strip of the medication to a soft-bristled toothbrush, and brush your teeth for at least 1 minute. Spit out the medication after use and rinse your mouth thoroughly. Do not swallow the medication. Make sure to brush all sensitive areas of the teeth.
Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time each day.
Do not use this medication for longer than 4 weeks unless directed by your doctor/dentist. Sensitive/painful teeth may sometimes be a symptom of a serious problem that needs attention from a dentist.
Inform your doctor/dentist if your symptoms persist or worsen.
Mouth/gum irritation may infrequently occur. If this effect persists or worsens, contact your doctor/dentist or pharmacist promptly.
Tell your doctor/dentist immediately if your teeth become stained or pitted. This is often a result of too much fluoride.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor/dentist or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.
Before using this medication, tell your doctor/dentist or pharmacist of all prescription and nonprescription/herbal products you may use, especially: other dental products.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
This medication may be harmful if swallowed in large amounts. If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: burning in the mouth, sore tongue, nausea/vomiting, diarrhea, increased saliva, stomach pain/cramping, muscle weakness, shaking, seizures.
NOTES:Do not share this medication with others.
Using this medication does not replace good dental habits. Continue to floss your teeth regularly as directed by your dentist, and have regular dental checkups.
Sensitive teeth can be caused by damage to the hard outside surface of the tooth (enamel). Avoid acidic food/drinks (such as ginger ale, limes/lemons, citrus-based drinks, coffee), which can damage the tooth enamel. Consult your doctor/dentist for more details.
MISSED DOSE:If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
STORAGE:Store at room temperature between 68-77 degrees F (20-25 degrees C) away from heat. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised May 2010 Copyright(c) 2010 First DataBank, Inc.
Before using this medication, tell your doctor/dentist or pharmacist if you are allergic to sodium fluoride or potassium nitrate; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor/dentist or pharmacist your medical history, especially of: mouth problems (e.g., sores, mucositis).
Tell your doctor if you are pregnant before using this medication.
This medication passes into breast milk. Consult your doctor before breast-feeding.
| Sodium fluoride | |
|---|---|
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IUPAC name
Sodium fluoride |
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Other names
Florocid |
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| Identifiers | |
| CAS number | 7681-49-4  Y |
| PubChem | 5235 |
| ChemSpider | 5045 Y |
| UNII | 8ZYQ1474W7 Y |
| EC number | 231-667-8 |
| UN number | 1690 |
| KEGG | C08142  N |
| ChEBI | CHEBI:28741 Y |
| ChEMBL | CHEMBL1528 Y |
| RTECS number | WB0350000 |
| ATC code | A01AA01,A12CD01, V09IX06 (18F) |
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InChI
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| Properties | |
| Molecular formula | NaF |
| Molar mass | 41.988173 g/mol |
| Appearance | White solid |
| Odor | odorless |
| Density | 2.558 g/cm3 |
| Melting point |
993 °C, 1266 K, 1819 °F |
| Boiling point |
1704 °C, 1977 K, 3099 °F |
| Solubility in water | 4.0 (15°); 4.3 (25°); 5.0 (100°) g/100mL |
| Solubility | soluble in HF insoluble in alcohol |
| Vapor pressure | 1 mmHg @ 1077 C°[1] |
| Refractive index (nD) | 1.336 |
| Structure | |
| Crystal structure | cubic |
| Hazards | |
| MSDS | Sodium fluoride MSDS |
| EU Index | 009-004-00-7 |
| EU classification | Toxic (T) Irritant (Xi) |
| R-phrases | R25, R32, R36/38 |
| S-phrases | (S1/2), S22, S36, S45 |
| NFPA 704 |
 0
3
0
|
| Flash point | Non-flammable |
| LD50 | 52–200 mg/kg (oral in rats, mice, rabbits)[2] |
| Related compounds | |
| Other anions | Sodium chloride Sodium bromide Sodium iodide |
| Other cations | Lithium fluoride Potassium fluoride Rubidium fluoride Caesium fluoride |
| Related compounds | TASF reagent |
 N (verify) (what is:  Y/ N?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Sodium fluoride is an inorganic chemical compound with the formula NaF. A colorless solid, it is a source of the fluoride ion in diverse applications. Sodium fluoride is less expensive and less hygroscopic than the related salt potassium fluoride.
Contents
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Structure, general properties, occurrence
Sodium fluoride is an ionic compound, dissolving to give separated Na+ and F− ions. Like sodium chloride, it crystallizes in a cubic motif where both Na+ and F− occupy octahedral coordination sites.[3][4]
The mineral form of NaF, villiaumite, is moderately rare. It is known from plutonic nepheline syenite rocks.[5]
Production
NaF is prepared by neutralizing hydrofluoric acid or hexafluorosilicic acid (H2SiF6), byproducts of the production of superphosphate fertilizer. Neutralizing agents include sodium hydroxide and sodium carbonate. Alcohols are sometimes used to precipitate the NaF:
- HF + NaOH → NaF + H2O
From solutions containing HF, sodium fluoride precipitates as the bifluoride salt NaHF2. Heating the latter releases HF and gives NaF.
- HF + NaF ⇌ NaHF2
In a 1986 report, the annual worldwide consumption of NaF was estimated to be several million tonnes.[6]
Applications
Fluoride salts are used to enhance the strength of teeth by the formation of fluorapatite, a naturally occurring component of tooth enamel.[7][8] Although sodium fluoride is also used to fluoridate water and, indeed, is the standard by which other water-fluoridation compounds are gauged, hexafluorosilicic acid (H2SiF6) and its salt sodium hexafluorosilicate (Na2SiF6) are more commonly used additives in the U.S.[9] Toothpaste often contains sodium fluoride to prevent cavities.[10] Alternatively, sodium fluoride is used as a cleaning agent, e.g. as a "laundry sour".[6] A variety of specialty chemical applications exist in synthesis and extractive metallurgy. It reacts with electrophilic chlorides including acyl chlorides, sulfur chlorides, and phosphorus chloride.[11] Like other fluorides, sodium fluoride finds use in desilylation in organic synthesis. The fluoride is the reagent for the synthesis of fluorocarbons.
In medical imaging, fluorine-18-labelled sodium fluoride is used in positron emission tomography (PET). Relative to conventional bone scintigraphy carried out with gamma cameras or SPECT systems, PET offers more sensitivity and spatial resolution. A disadvantage of PET is that fluorine-18 labelled sodium fluoride is less widely available than conventional technetium-99m-labelled radiopharmaceuticals.
Safety
The lethal dose for a 70 kg (154 lb) human is estimated at 5–10 g.[6] Sodium fluoride is classed as toxic by both inhalation (of dusts or aerosols) and ingestion.[12] In high enough doses, it has been shown to affect the heart and circulatory system.
In the higher doses used to treat osteoporosis, plain sodium fluoride can cause pain in the legs and incomplete stress fractures when the doses are too high; it also irritates the stomach, sometimes so severely as to cause ulcers. Slow-release and enteric-coated versions of sodium fluoride do not have gastric side effects in any significant way, and have milder and less frequent complications in the bones.[13] In the lower doses used for water fluoridation, the only clear adverse effect is dental fluorosis, which can alter the appearance of children's teeth during tooth development; this is mostly mild and is unlikely to represent any real effect on aesthetic appearance or on public health.[14]
See also
- Fluorine
- Cryolite
References
- ^ Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 10th ed. Volumes 1-3 New York, NY: John Wiley & Sons Inc., 1999., p. 3248
- ^ Martel, B.; Cassidy, K. (2004), Chemical Risk Analysis: A Practical Handbook, Butterworth–Heinemann, p. 363, ISBN 1-903996-65-1
- ^ Wells, A.F. (1984), Structural Inorganic Chemistry, Oxford: Clarendon Press, ISBN 0-19-855370-6
- ^ "Chemical and physical information" (PDF), Toxicological profile for fluorides, hydrogen fluoride, and fluorine, Agency for Toxic Substances and Disease Registry (ATDSR), September 2003, pp. 187, http://www.atsdr.cdc.gov/toxprofiles/tp11.pdf, retrieved 2008-11-01
- ^ (PDF) Mineral Handbook, Mineral Data Publishing, 2005, http://rruff.geo.arizona.edu/doclib/hom/villiaumite.pdf.
- ^ a b c Aigueperse, Jean; Paul Mollard, Didier Devilliers, Marius Chemla, Robert Faron, Renée Romano, Jean Pierre Cuer (2005), "Fluorine Compounds, Inorganic", in Ullmann, Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH, doi:10.1002/14356007.a11_307
- ^ Bourne, Geoffrey Howard (1986), Dietary research and guidance in health and disease, Karger, p. 153, ISBN 3-8055-4341-7, http://books.google.com/?id=OW0gAAAAMAAJ , Snippet view from page 153
- ^ Klein, Cornelis; Hurlbut, Cornelius Searle; Dana, James Dwight (1999), Manual of Mineralogy (21 ed.), Wiley, ISBN 0-471-31266-5
- ^ Division of Oral Health, National Center for Prevention Services, CDC (1993) (PDF), Fluoridation census 1992, http://cdc.gov/fluoridation/pdf/statistics/1992.pdf, retrieved 2008-12-29.
- ^ "Sodium fluoride, Molecule of the week". American Chemical Society. 2008-02-19. http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=841&content_id=WPCP_008239&use_sec=true&sec_url_var=region1. Retrieved 2008-11-01.
- ^ Halpern, D.F. (2001), "Sodium Fluoride", Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, doi:10.1002/047084289X.rs071
- ^ http://hazard.com/msds/mf/baker/baker/files/s3722.htm NaF MSDS
- ^ Murray TM, Ste-Marie LG. Prevention and management of osteoporosis: consensus statements from the Scientific Advisory Board of the Osteoporosis Society of Canada. 7. Fluoride therapy for osteoporosis. CMAJ. 1996;155(7):949–54. PMID 8837545.
- ^ National Health and Medical Research Council (Australia). A systematic review of the efficacy and safety of fluoridation [PDF]. 2007. ISBN 1-86496-415-4. Summary: Yeung CA. A systematic review of the efficacy and safety of fluoridation. Evid Based Dent. 2008;9(2):39–43. doi:10.1038/sj.ebd.6400578. PMID 18584000. Lay summary: NHMRC, 2007.
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What conditions does sodium fluoride-pot nitrate Dent treat?
sodium fluoride-pot nitrate Dent is used to treat the following:
Tooth Decay Prevention
sodium fluoride-pot nitrate Dent may also be used to treat:
Prevention of Tooth Plaque, Inflammation of the Gums
Who should not take sodium fluoride-pot nitrate Dent?
Check with your physician if you have any of the following:
Conditions:
Excess Fluoride in the Teeth causing Discoloration
Allergies:
FLUORIDE PREPARATIONS
Does sodium fluoride-pot nitrate Dent have side effects?
The following side effects are associated with sodium fluoride-pot nitrate Dent:
Rare side effects of sodium fluoride-pot nitrate Dent:
| Excess Fluoride in the Teeth causing Discoloration | Severe |
| Canker Sore | Severe |
Should I avoid certain foods while taking sodium fluoride-pot nitrate Dent?
There is no food interaction information available for sodium fluoride-pot nitrate Dent at this time. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
Does sodium fluoride-pot nitrate Dent interact with other medications?
There is no drug interaction information available for sodium fluoride-pot nitrate Dent at this time. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
